Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683244 | 0.89 | SIGMAR1 (0.54) | HTR1ADRD2MAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL9681380 | 0.88 | SIGMAR1 (0.53) | HTR1ADRD2MAPTALDH1A1LMNA | |
| SCHEMBL9681419 | 0.87 | KDM4E (0.49) | MAPTALDH1A1LMNAPOLBMAPK1 | |
| SCHEMBL9680605 | 0.87 | DRD2 (0.57) | HTR1ADRD2MAPTALDH1A1LMNA | |
| SCHEMBL9682450 | 0.86 | DRD4 (0.58) | HTR1ADRD2MAPTALDH1A1LMNA | |
| SCHEMBL9680805 | 0.84 | DRD3 (0.43) | HTR1ADRD2MAPTALDH1A1LMNA | |
| SCHEMBL9680636 | 0.83 | SMO (0.50) | MAPTALDH1A1LMNAMAPK1HSD17B10 | |
| SCHEMBL6125292 | 0.82 | KHK (0.56) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9682152 | 0.81 | KHK (0.54) | ALDH1A1 | |
| SCHEMBL9681924 | 0.81 | HTR1A (0.47) | HTR1AMAPTALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |