Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.71 |
| ▸ | DRD2 | P14416 | 11/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 11/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699191 | 0.88 | PTGDR2 (0.66) | PTGDR2DRD2TBXA2RL3MBTL1 | |
| SCHEMBL9581575 | 0.87 | TBXA2R (0.58) | PTGDR2DRD2TBXA2R | |
| SCHEMBL9682042 | 0.86 | PTGDR2 (0.53) | PTGDR2DRD2TBXA2RL3MBTL1 | |
| SCHEMBL9700228 | 0.85 | ALDH1A1 (0.60) | PTGDR2TBXA2R | |
| SCHEMBL9683188 | 0.85 | L3MBTL1 (0.74) | PTGDR2DRD2TBXA2RL3MBTL1HDAC3 | |
| SCHEMBL9699174 | 0.84 | PTGDR2 (0.55) | PTGDR2DRD2TBXA2R | |
| SCHEMBL9682472 | 0.84 | TBXA2R (0.57) | PTGDR2DRD2TBXA2R | |
| SCHEMBL5109787 | 0.83 | PTGDR2 (1.00) | PTGDR2 | |
| SCHEMBL7035111 | 0.82 | PTGDR2 (0.69) | PTGDR2L3MBTL1 | |
| SCHEMBL7030671 | 0.81 | PTGDR2 (0.67) | PTGDR2L3MBTL1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5021443-A | Noval benzimidazole and azabenzimiazole derivatives which are thromboxane receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present | LABORATOIRES UPSA (FR) | 1991-06-04 | — | — | US | disclosed |