Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 6/20 | 0.42 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683453 | 0.71 | OPRM1 (0.35) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9684167 | 0.69 | ALDH1A1 (0.31) | — | |
| SCHEMBL9683465 | 0.68 | CARM1 (0.33) | HTR1ADRD2DRD3SLC6A2ADRA2A | |
| SCHEMBL9684281 | 0.67 | OPRM1 (0.37) | SIGMAR1 | |
| SCHEMBL9683338 | 0.66 | POLB (0.34) | — | |
| SCHEMBL9684260 | 0.64 | DUT (0.33) | — | |
| SCHEMBL26108581 | 0.64 | HTR1A (0.65) | HTR1ADRD2DRD3DRD4HTR7 | |
| SCHEMBL26492991 | 0.64 | HTR1A (0.65) | HTR1ADRD2DRD3DRD4HTR7 | |
| SCHEMBL23252522 | 0.63 | HTR1A (0.53) | KDM1AHTR1ADRD2DRD3DRD4 | |
| SCHEMBL1307809 | 0.63 | POLB (0.53) | KDM1AHTR1ADRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475187-A1 | Naphthothiophenimines for treating neuronal disorders caused by ischemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1992-03-18 | — | — | EP | disclosed |
| US-5064831-A | N-methyl-d-aspartate receptor antagonist | BRISTOL-MYERS SQUIBB CO. (US) | 1991-11-12 | — | — | US | disclosed |