Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.57 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.49 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682997 | 0.92 | FAAH (0.57) | FAAHSPHK1SPHK2 | |
| SCHEMBL9745126 | 0.75 | FAAH (0.48) | FAAHSPHK1SPHK2 | |
| SCHEMBL8408488 | 0.75 | GBA1 (0.48) | POLB | |
| SCHEMBL22587046 | 0.75 | VEGFA (0.53) | FAAH | |
| SCHEMBL9592739 | 0.75 | SIGMAR1 (0.60) | LTA4H | |
| SCHEMBL11990400 | 0.74 | GBA1 (0.49) | — | |
| SCHEMBL1177664 | 0.74 | FAAH (0.48) | FAAHSPHK1SPHK2 | |
| SCHEMBL4158989 | 0.74 | ABHD6 (0.47) | NPC1RAB9A | |
| SCHEMBL7297678 | 0.74 | FAAH (0.60) | FAAHSPHK1SPHK2LTA4H | |
| SCHEMBL28829172 | 0.74 | FAAH (0.61) | FAAHSPHK1SPHK2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130309-A | Cardiovascular disorders | A. H. ROBINS COMPANY, INCORPORATED (US) | 1992-07-14 | — | — | US | disclosed |