Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.62 |
| ▸ | MME | P08473 | 3/20 | 0.53 |
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | ECE1 | P42892 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL489231 | 0.99 | MMEL1 (0.64) | MMEL1MMEACEECE1 | |
| SCHEMBL489232 | 0.99 | MMEL1 (0.64) | MMEL1MMEACEECE1 | |
| SCHEMBL7316768 | 0.92 | MMEL1 (0.55) | MMEL1MMEACEECE1 | |
| SCHEMBL9683662 | 0.91 | MMEL1 (0.54) | MMEL1MMEACEECE1 | |
| SCHEMBL9682406 | 0.91 | MMEL1 (0.54) | MMEL1MMEACEECE1 | |
| SCHEMBL7343519 | 0.91 | MMEL1 (0.54) | MMEL1MMEACEECE1 | |
| SCHEMBL7310571 | 0.90 | MMEL1 (0.53) | MMEL1MMEACEECE1 | |
| SCHEMBL15202503 | 0.87 | L3MBTL1 (0.63) | MMEL1MMEACEECE1 | |
| SCHEMBL7319125 | 0.86 | MME (0.55) | MMEACEECE1 | |
| SCHEMBL7338163 | 0.86 | MMEL1 (0.49) | MMEL1MMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511940-A2 | Phosphono/biaryl substituted dipeptide derivatives | CIBA-GEIGY AG (CH) | 1992-11-04 | — | — | EP | claimed |
| EP-0511940-A2 | Phosphono/biaryl substituted dipeptide derivatives | CIBA-GEIGY AG (CH) | 1992-11-04 | — | — | EP | disclosed |