Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.59 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685068 | 0.89 | TRPA1 (0.64) | TRPA1PTPN11LMNAHTTKDM4E | |
| SCHEMBL9686751 | 0.86 | TRPA1 (0.61) | TRPA1PTPN11LMNAHTTKDM4E | |
| SCHEMBL9685091 | 0.84 | TRPA1 (0.59) | TRPA1PTPN11LMNAHTTKDM4E | |
| SCHEMBL9686656 | 0.83 | TRPA1 (0.49) | TRPA1PTPN11LMNAHTT | |
| SCHEMBL10824572 | 0.80 | NPC1 (0.44) | TRPA1MAPT | |
| SCHEMBL9685186 | 0.80 | PARP1 (0.38) | TRPA1 | |
| SCHEMBL9686176 | 0.78 | TRPA1 (0.57) | TRPA1LMNAHTTKDM4EALOX15 | |
| SCHEMBL9686187 | 0.76 | TRPA1 (0.52) | TRPA1PTPN11LMNAHTTKDM4E | |
| SCHEMBL9685390 | 0.76 | TRPA1 (0.60) | TRPA1PTPN11LMNAHTTKDM4E | |
| SCHEMBL9685239 | 0.76 | TRPA1 (0.60) | TRPA1PTPN11LMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |