Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684409 | 0.83 | TRPA1 (0.59) | TRPA1LMNAHTTPTPN11 | |
| SCHEMBL9685139 | 0.75 | TRPA1 (0.56) | TRPA1LMNAHTTPTPN11BCL2L1 | |
| SCHEMBL9686160 | 0.73 | TRPA1 (0.54) | TRPA1LMNAHTTPTPN11BCL2L1 | |
| SCHEMBL10824572 | 0.73 | NPC1 (0.44) | TRPA1NPC1RAB9A | |
| SCHEMBL9685068 | 0.73 | TRPA1 (0.64) | TRPA1LMNAHTTPTPN11NPC1 | |
| SCHEMBL9686157 | 0.73 | NPSR1 (0.55) | TRPA1LMNAHTTPTPN11RAB9A | |
| SCHEMBL9298122 | 0.72 | PRMT1 (0.51) | TRPA1LMNAHTTPTPN11RAB9A | |
| SCHEMBL9684629 | 0.72 | PRMT1 (0.51) | TRPA1LMNAHTTPTPN11RAB9A | |
| SCHEMBL9685390 | 0.72 | TRPA1 (0.60) | TRPA1LMNAHTTPTPN11NPC1 | |
| SCHEMBL9685239 | 0.72 | TRPA1 (0.60) | TRPA1LMNAHTTPTPN11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |