Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9685068 | 0.83 | TRPA1 (0.64) | TRPA1ACHEKDM4EMAPTMAPK1 | |
| SCHEMBL9686751 | 0.80 | TRPA1 (0.61) | TRPA1KDM4EMAPTMAPK1NPSR1 | |
| SCHEMBL9685091 | 0.78 | TRPA1 (0.59) | TRPA1KDM4EMAPTMAPK1NPSR1 | |
| SCHEMBL9684409 | 0.78 | TRPA1 (0.59) | TRPA1KDM4EMAPTMAPK1NPSR1 | |
| SCHEMBL9686187 | 0.76 | TRPA1 (0.52) | TRPA1ACHEKDM4EMAPTMAPK1 | |
| SCHEMBL9685390 | 0.76 | TRPA1 (0.60) | TRPA1KDM4EHDAC6LMNAHTT | |
| SCHEMBL9685239 | 0.76 | TRPA1 (0.60) | TRPA1KDM4EMAPTNPSR1HDAC6 | |
| SCHEMBL8812740 | 0.73 | LMNA (0.52) | TRPA1ACHEHDAC6LMNAHTT | |
| SCHEMBL8812814 | 0.73 | KDM4E (0.51) | TRPA1ACHEKDM4EMAPTMAPK1 | |
| SCHEMBL8810744 | 0.72 | HTT (0.46) | TRPA1ACHEMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |