Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | VEGFA | P15692 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13404501 | 0.71 | HTR3E (0.54) | DRD4DRD2DRD3ALDH1A1TSHR | |
| SCHEMBL9686771 | 0.69 | GRM2 (0.38) | ALDH1A1VEGFAEGLN1TSHRMEN1 | |
| SCHEMBL9684556 | 0.68 | LMNA (0.51) | DRD2ALDH1A1TSHRMEN1MAPK1 | |
| SCHEMBL13404452 | 0.65 | TSHR (0.58) | DRD4DRD2DRD3ALDH1A1TSHR | |
| SCHEMBL9686777 | 0.65 | GRM2 (0.48) | ALDH1A1EGLN1TSHRMAPK1HTT | |
| SCHEMBL6661493 | 0.63 | SIGMAR1 (0.78) | DRD4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL878682 | 0.63 | SIGMAR1 (0.78) | DRD4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1045589 | 0.63 | SIGMAR1 (0.78) | DRD4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8188324 | 0.61 | SIGMAR1 (1.00) | DRD4KMT2ALMNASIGMAR1 | |
| SCHEMBL2489199 | 0.61 | SIGMAR1 (1.00) | DRD4KMT2ALMNASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61057581-A | — | — | None | — | — | JP | disclosed |
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| EP-0188094-A2 | Quinazoline derivatives and antihypertensive preparations containing same as effective components | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |
| JP-S6157581-A | 1,4-DIHYDRO-2-PIPERAZINOPYRIDOPYRIMIDINE DERIVATIVE | MITSUI PETROCHEM IND LTD | 1986-03-24 | — | — | JP | disclosed |