Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 7/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP5 | P51878 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9684556 | 0.79 | LMNA (0.51) | GRM2ALDH1A1LMNAMAPK1KDM4E | |
| SCHEMBL13404501 | 0.71 | HTR3E (0.54) | ALDH1A1LMNAMAPK1KDM4ETSHR | |
| SCHEMBL10824274 | 0.70 | NPC1 (0.48) | GRM2ALDH1A1LMNAMAPK1KDM4E | |
| SCHEMBL5320344 | 0.66 | KDM4E (0.65) | GRM2ALDH1A1LMNAMAPK1KDM4E | |
| SCHEMBL13404452 | 0.65 | TSHR (0.58) | ALDH1A1LMNAKDM4ENPSR1TSHR | |
| SCHEMBL11384876 | 0.65 | CASP1 (0.66) | ALDH1A1LMNAMAPK1KDM4ENPSR1 | |
| SCHEMBL9684487 | 0.65 | DRD4 (0.45) | GRM2ALDH1A1LMNAMAPK1KDM4E | |
| SCHEMBL9686858 | 0.64 | HTR3A (0.55) | ALDH1A1LMNAMAPK1KDM4ETSHR | |
| SCHEMBL9686660 | 0.64 | HTT (0.48) | ALDH1A1LMNAMAPK1KDM4ENPSR1 | |
| SCHEMBL1083795 | 0.63 | HTR3A (0.68) | ALDH1A1LMNAMAPK1KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188094-B1 | QUINAZOLINE DERIVATIVES AND ANTIHYPERTENSIVE PREPARATIONS CONTAINING SAME AS EFFECTIVE COMPONENTS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-4734418-A | Quinazoline compounds and antihypertensives | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1988-03-29 | — | — | US | disclosed |