Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATP4A | P20648 | 3/20 | 0.40 |
| ▸ | ATP4B | P51164 | 3/20 | 0.40 |
| ▸ | TNF | P01375 | 3/20 | 0.39 |
| ▸ | LITAF | Q99732 | 3/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8130885 | 0.78 | KDM4E (0.48) | KDM4EHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL24008926 | 0.75 | KDM4E (0.48) | KDM4EHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6381401 | 0.71 | HPGDS (0.54) | KDM4EHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL29254511 | 0.71 | KDM4E (0.48) | KDM4EHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL11065307 | 0.71 | ATP4A (0.51) | HTR1AADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL9652279 | 0.70 | MEN1 (0.48) | MEN1KMT2A | |
| SCHEMBL9685516 | 0.70 | KDM4E (0.77) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8537645 | 0.70 | MEN1 (0.48) | MEN1KMT2A | |
| SCHEMBL28926222 | 0.70 | PIN1 (0.53) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL1257667 | 0.70 | MEN1 (0.51) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307078-B1 | QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1992-08-26 | — | — | EP | disclosed |
| US-5051508-A | Antisecretory agents and enzyme inhibitors as antiulcer agents | SMITHKLINE BECKMAN INTERCREDIT B.V. (NL) | 1991-09-24 | — | — | US | disclosed |
| EP-0307078-A1 | Quinoline derivatives, process for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1989-03-15 | — | — | EP | disclosed |