Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.68 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.58 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.58 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 4/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KDM4A | O75164 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234462 | 0.94 | SIGMAR1 (0.65) | SIGMAR1CARM1PRMT6PRMT8MAOB | |
| SCHEMBL29733117 | 0.88 | SIGMAR1 (0.85) | SIGMAR1CARM1PRMT6PRMT8MAOB | |
| SCHEMBL7225346 | 0.88 | SIGMAR1 (0.85) | SIGMAR1CARM1PRMT6PRMT8MAOB | |
| SCHEMBL3377392 | 0.86 | CARM1 (0.64) | SIGMAR1CARM1PRMT6PRMT8MAOB | |
| SCHEMBL1088446 | 0.86 | SIGMAR1 (0.74) | SIGMAR1CARM1PRMT6PRMT8MAOB | |
| Hydrochloric Acid SCHEMBL1087168 | 0.84 | SIGMAR1 (0.71) | SIGMAR1CARM1PRMT6PRMT8MAOB | |
| SCHEMBL2749362 | 0.82 | SIGMAR1 (0.70) | SIGMAR1CARM1PRMT6PRMT8MAOB | |
| SCHEMBL16260101 | 0.82 | SIGMAR1 (0.76) | SIGMAR1CARM1PRMT6PRMT8MAOB | |
| SCHEMBL7055109 | 0.81 | CARM1 (0.75) | SIGMAR1CARM1PRMT6PRMT8MAOB | |
| SCHEMBL4604745 | 0.81 | CARM1 (0.75) | SIGMAR1CARM1PRMT6PRMT8MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159040-B1 | PYRIDINE DERIVATIVES AND PRODUCTION THEREOF | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1992-12-09 | — | — | EP | disclosed |
| US-5036059-A | Hypotensive agents, vasodilators | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1991-07-30 | — | — | US | disclosed |
| EP-0121117-B1 | DERIVATIVES OF DIHYDROPYRIDINE AND PRODUCTION THEREOF | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1989-08-30 | — | — | EP | disclosed |
| EP-0159040-A2 | Pyridine derivatives and production thereof | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4535073-A | VASODILATION | NIPPON SHINYAKU CO LIMITED (JP) | 1985-08-13 | — | — | US | disclosed |
| EP-0121117-A1 | Derivatives of dihydropyridine and production thereof | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1984-10-10 | — | — | EP | disclosed |