Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | FADS1 | O60427 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3481659 | 0.85 | MAPT (0.59) | MAPTSMN1; SMN2L3MBTL1CYP1A2KDM4E | |
| SCHEMBL9653610 | 0.82 | MAPT (0.56) | MAPTSMN1; SMN2L3MBTL1CYP1A2KDM4E | |
| SCHEMBL9563510 | 0.81 | MAPT (0.56) | MAPTSMN1; SMN2L3MBTL1CYP1A2KDM4E | |
| SCHEMBL9563508 | 0.81 | KEAP1 (0.54) | MAPTSMN1; SMN2L3MBTL1CYP1A2KDM4E | |
| SCHEMBL9540049 | 0.80 | RECQL (0.79) | SMN1; SMN2KDM4ERECQLKMT2AFADS1 | |
| SCHEMBL12683906 | 0.80 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2L3MBTL1CYP1A2KDM4E | |
| SCHEMBL18080777 | 0.80 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2L3MBTL1CYP1A2KDM4E | |
| SCHEMBL6351799 | 0.78 | RECQL (0.64) | MAPTSMN1; SMN2RECQLKMT2AFADS1 | |
| SCHEMBL9684971 | 0.77 | IDO1 (0.57) | MAPTSMN1; SMN2L3MBTL1CYP1A2KDM4E | |
| SCHEMBL9851289 | 0.77 | MAPT (1.00) | MAPTSMN1; SMN2L3MBTL1CYP1A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9446048-B2 | Methods for treating leukemia and disorders mediated by CBFβ and RUNX1 proteins | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-09-20 | — | — | US | disclosed |
| US-9446048-B2 | Methods for treating leukemia and disorders mediated by CBFβ and RUNX1 proteins | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-09-20 | — | — | US | disclosed |
| EP-2685985-B1 | METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBF AND RUNX1 PROTEINS | US HEALTH (US) | 2016-08-31 | — | — | EP | disclosed |
| WO-2012125787-A1 | METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBFβ AND RUNX1 PROTEINS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC (US) | 2012-09-20 | — | — | WO | disclosed |
| CN-1062528-A | BENZODIAZEPINONE | HOFFMANN LA ROCHE (CH) | 1992-07-08 | — | — | CN | disclosed |
| EP-0491218-A1 | Benzodiazepinones | F. HOFFMANN-LA ROCHE AG (CH) | 1992-06-24 | — | — | EP | disclosed |