Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 3/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686545 | 0.81 | MAPT (0.49) | NOS3NOS2TLR8ALDH1A1POLB | |
| SCHEMBL9687045 | 0.81 | NOS2 (0.39) | NOS3NOS2TLR8ALDH1A1POLB | |
| SCHEMBL4986132 | 0.74 | NOS2 (0.42) | NOS3NOS2TLR8ALDH1A1POLB | |
| SCHEMBL9387184 | 0.71 | GAA (0.40) | NOS3NOS2ALDH1A1POLBTDP1 | |
| SCHEMBL9686513 | 0.70 | NOS2 (0.41) | NOS3NOS2TLR8 | |
| SCHEMBL4987971 | 0.68 | NOS2 (0.42) | NOS3NOS2TLR8 | |
| SCHEMBL3264472 | 0.67 | NOS2 (0.52) | NOS3NOS2TLR8 | |
| SCHEMBL9687039 | 0.67 | NOS2 (0.44) | NOS3NOS2 | |
| SCHEMBL9536189 | 0.66 | NOS2 (0.47) | NOS3NOS2ALDH1A1 | |
| SCHEMBL9687757 | 0.66 | NOS2 (0.47) | NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |
| US-5006527-A | Antihistamines, antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-09 | — | — | US | disclosed |
| EP-0295742-A1 | Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-21 | — | — | EP | disclosed |