Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 5/20 | 0.43 |
| ▸ | NOS3 | P29474 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687045 | 0.84 | NOS2 (0.39) | MAPTPOLBALDH1A1L3MBTL1THRB | |
| SCHEMBL9686463 | 0.81 | NOS3 (0.37) | MAPTPOLBALDH1A1L3MBTL1THRB | |
| SCHEMBL4986132 | 0.79 | NOS2 (0.42) | MAPTPOLBALDH1A1L3MBTL1THRB | |
| SCHEMBL9686513 | 0.75 | NOS2 (0.41) | NOS2NOS3MEN1KMT2ATLR8 | |
| SCHEMBL9686525 | 0.74 | MAPT (0.49) | MAPTPOLBALDH1A1L3MBTL1THRB | |
| SCHEMBL9687484 | 0.73 | MAPT (0.44) | MAPTPOLBALDH1A1L3MBTL1THRB | |
| SCHEMBL9387184 | 0.73 | GAA (0.40) | POLBALDH1A1TDP1NOS2NOS3 | |
| SCHEMBL4462978 | 0.73 | ALDH1A1 (0.51) | MAPTPOLBALDH1A1L3MBTL1THRB | |
| SCHEMBL4987971 | 0.73 | NOS2 (0.42) | NOS2NOS3TLR8NOS1 | |
| SCHEMBL9687039 | 0.72 | NOS2 (0.44) | NOS2NOS3ALOX5NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297661-B1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-16 | — | — | EP | disclosed |
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |
| EP-0297661-A1 | [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-04 | — | — | EP | disclosed |
| EP-0295742-A1 | Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-21 | — | — | EP | disclosed |