Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 6/20 | 0.41 |
| ▸ | NOS3 | P29474 | 5/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686545 | 0.75 | MAPT (0.49) | NOS2NOS3NOS1TLR8MEN1 | |
| SCHEMBL9387184 | 0.74 | GAA (0.40) | NOS2NOS3KDM4EMEN1KMT2A | |
| SCHEMBL4986132 | 0.74 | NOS2 (0.42) | NOS2NOS3NOS1TLR8 | |
| SCHEMBL9687039 | 0.73 | NOS2 (0.44) | NOS2NOS3NOS1 | |
| SCHEMBL9536189 | 0.72 | NOS2 (0.47) | NOS2NOS3NOS1 | |
| SCHEMBL9687045 | 0.72 | NOS2 (0.39) | NOS2NOS3NOS1TLR8 | |
| SCHEMBL22068695 | 0.72 | NOS2 (0.47) | NOS2NOS3NOS1KDM4EMEN1 | |
| SCHEMBL9687757 | 0.72 | NOS2 (0.47) | NOS2NOS3NOS1 | |
| SCHEMBL25256924 | 0.70 | NOS2 (0.41) | NOS2NOS3NOS1 | |
| SCHEMBL9686463 | 0.70 | NOS3 (0.37) | NOS2NOS3TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |