Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686545 | 0.74 | MAPT (0.49) | MAPTHTTALDH1A1L3MBTL1POLB | |
| SCHEMBL8392797 | 0.70 | LTB4R (0.44) | MAPTHTTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL9687484 | 0.70 | MAPT (0.44) | MAPTHTTALDH1A1L3MBTL1POLB | |
| SCHEMBL903315 | 0.70 | CHRM2 (0.58) | MAPTHTTALDH1A1L3MBTL1POLB | |
| SCHEMBL3064440 | 0.69 | NOS2 (0.42) | MAPTHTTPOLBTDP1MEN1 | |
| SCHEMBL9539887 | 0.68 | PARP1 (0.38) | ALDH1A1NPC1 | |
| SCHEMBL8012674 | 0.68 | ALDH1A1 (0.41) | MAPTALDH1A1POLBLMNAHSP90AB1 | |
| SCHEMBL1743766 | 0.68 | PDE3B (0.54) | ALDH1A1POLBMEN1KMT2AHPGD | |
| SCHEMBL19481502 | 0.68 | CHRM2 (0.56) | MAPTHTTALDH1A1L3MBTL1POLB | |
| Hydrochloric Acid SCHEMBL10428785 | 0.67 | MAOB (0.38) | MAPTALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295742-B1 | NOVEL N-(4-PIPERIDINYL) BICYCLIC CONDENSED 2-IMIDAZOLAMINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-26 | — | — | EP | disclosed |
| EP-0295742-A1 | Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-21 | — | — | EP | disclosed |