Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24373936 | 0.65 | DRD2 (0.42) | ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL20075377 | 0.64 | ADORA2A (0.47) | LMNAKDM4EALDH1A1HPGDGAA | |
| SCHEMBL18987920 | 0.64 | MEN1 (0.47) | LMNAKDM4EALDH1A1HPGDHTT | |
| SCHEMBL11543788 | 0.63 | LMNA (0.41) | LMNAKDM4EALDH1A1POLBGAA | |
| SCHEMBL5740490 | 0.62 | LMNA (0.44) | LMNAKDM4EALDH1A1POLBHPGD | |
| SCHEMBL7922166 | 0.61 | LMNA (0.41) | LMNAKDM4EALDH1A1POLBHPGD | |
| SCHEMBL8788378 | 0.59 | PARP1 (0.32) | KDM4EALDH1A1 | |
| SCHEMBL11546547 | 0.59 | LMNA (0.51) | LMNAKDM4EALDH1A1POLBGAA | |
| SCHEMBL11549662 | 0.58 | LRRK2 (0.46) | LMNAKDM4EALDH1A1POLBHPGD | |
| SCHEMBL16446184 | 0.58 | LMNA (0.38) | LMNAKDM4EALDH1A1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273176-B1 | FUSED HETEROCYCLIC TETRAHYDROAMINOQUINOLINOLS AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-06-24 | — | — | EP | disclosed |
| EP-0273176-A2 | Fused heterocyclic tetrahydroaminoquinolinols and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-07-06 | — | — | EP | disclosed |