Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 13/20 | 0.64 |
| ▸ | GABRG2 | P18507 | 13/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 13/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 13/20 | 0.64 |
| ▸ | GABRP | O00591 | 12/20 | 0.64 |
| ▸ | GABRD | O14764 | 12/20 | 0.64 |
| ▸ | GABRB1 | P18505 | 12/20 | 0.64 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.64 |
| ▸ | GABRB2 | P47870 | 12/20 | 0.64 |
| ▸ | GABRA4 | P48169 | 12/20 | 0.64 |
| ▸ | GABRE | P78334 | 12/20 | 0.64 |
| ▸ | GABRA6 | Q16445 | 12/20 | 0.64 |
| ▸ | GABRG1 | Q8N1C3 | 12/20 | 0.64 |
| ▸ | GABRG3 | Q99928 | 12/20 | 0.64 |
| ▸ | GABRQ | Q9UN88 | 12/20 | 0.64 |
| ▸ | UBE2N | P61088 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10405046 | 0.78 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9687518 | 0.78 | KDM4E (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9536896 | 0.77 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9689016 | 0.76 | FPR2 (0.41) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9689425 | 0.75 | HSPB1 (0.46) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9836444 | 0.74 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9839859 | 0.73 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8871379 | 0.73 | GABRA1 (0.74) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7502529 | 0.73 | GABRA1 (0.49) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9839115 | 0.73 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237467-B1 | HETEROARYL-OXY-BETA-CARBOLINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-10-28 | — | — | EP | disclosed |