Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6036822 | 0.85 | KEAP1 (0.59) | KEAP1NFE2L2CASP1SCN9AALDH1A1 | |
| SCHEMBL28553772 | 0.84 | KEAP1 (0.53) | KEAP1NFE2L2CASP1SCN9A | |
| SCHEMBL9687498 | 0.81 | CHRNB2 (0.38) | KEAP1NFE2L2ALDH1A1ALOX15 | |
| SCHEMBL31048928 | 0.75 | KEAP1 (0.71) | KEAP1NFE2L2CASP1ALDH1A1ALOX15 | |
| SCHEMBL919984 | 0.75 | KEAP1 (0.71) | KEAP1NFE2L2CASP1ALDH1A1ALOX15 | |
| SCHEMBL9687444 | 0.73 | LMNA (0.39) | CASP1 | |
| SCHEMBL113812 | 0.71 | KEAP1 (1.00) | KEAP1NFE2L2CASP1ALDH1A1 | |
| SCHEMBL29744459 | 0.71 | KEAP1 (1.00) | KEAP1NFE2L2CASP1ALDH1A1 | |
| SCHEMBL29260193 | 0.70 | KEAP1 (0.56) | KEAP1NFE2L2 | |
| SCHEMBL166218 | 0.69 | KEAP1 (0.69) | KEAP1NFE2L2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187376-B1 | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| EP-0187376-A2 | 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids | BAYER AG (DE) | 1986-07-16 | — | — | EP | disclosed |