Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687533 | 0.81 | KEAP1 (0.55) | KEAP1NFE2L2ALDH1A1ALOX15 | |
| SCHEMBL9687444 | 0.75 | LMNA (0.39) | MAPTATML3MBTL1LMNA | |
| SCHEMBL29781399 | 0.74 | LMNA (0.46) | NPSR1KMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL227733 | 0.74 | LMNA (0.46) | NPSR1KMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL31153184 | 0.72 | KEAP1 (0.44) | CHRNB2CHRNA4KEAP1NFE2L2MAPT | |
| SCHEMBL2565529 | 0.72 | KEAP1 (0.44) | CHRNB2CHRNA4KEAP1NFE2L2MAPT | |
| SCHEMBL5740998 | 0.72 | TDP1 (0.39) | KMT2ATDP1S1PR2ALDH1A1L3MBTL1 | |
| SCHEMBL7087131 | 0.71 | NFKB1 (0.37) | ALDH1A1 | |
| SCHEMBL2566963 | 0.68 | KEAP1 (0.64) | KEAP1NFE2L2KMT2AMEN1MAPT | |
| SCHEMBL29406550 | 0.68 | KEAP1 (0.64) | KEAP1NFE2L2KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187376-B1 | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| EP-0187376-A2 | 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids | BAYER AG (DE) | 1986-07-16 | — | — | EP | disclosed |