Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10553167 | 0.78 | HTT (0.42) | HTTATMVCAM1GPR35CASP1 | |
| SCHEMBL9687498 | 0.75 | CHRNB2 (0.38) | LMNAATML3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL10553172 | 0.73 | KEAP1 (0.51) | HTTATMVCAM1GPR35MAPT | |
| SCHEMBL29169624 | 0.73 | MAPT (0.35) | LMNAVCAM1GPR35MAPTSMN1; SMN2 | |
| SCHEMBL9687533 | 0.73 | KEAP1 (0.55) | CASP1 | |
| SCHEMBL3462389 | 0.72 | ALDH1A1 (0.50) | LMNAHTTL3MBTL1POLBMAPT | |
| SCHEMBL29757749 | 0.71 | TSHR (0.45) | LMNAHTTVCAM1GPR35L3MBTL1 | |
| SCHEMBL56541 | 0.71 | TSHR (0.45) | LMNAHTTVCAM1GPR35L3MBTL1 | |
| SCHEMBL31283123 | 0.69 | ALDH1A1 (0.56) | SENP8SENP7SENP6HTTGPR35 | |
| SCHEMBL223281 | 0.69 | ALDH1A1 (0.56) | SENP8SENP7SENP6HTTGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0187376-B1 | 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS | BAYER AG (DE) | 1992-05-13 | — | — | EP | disclosed |
| EP-0187376-A2 | 6,7-Disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids | BAYER AG (DE) | 1986-07-16 | — | — | EP | disclosed |