Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 5/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR5A | P47898 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
| ▸ | HTR1F | P30939 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688716 | 0.85 | JAK2 (0.47) | JAK2JAK1TYK2JAK3METAP2 | |
| SCHEMBL9688718 | 0.81 | HTR6 (0.34) | HTR6HTR7HTR5AHTR1AHTR1B | |
| SCHEMBL9689988 | 0.80 | ROCK2 (0.42) | METAP2HTR6HTR5AHTR1D | |
| SCHEMBL9688943 | 0.79 | JAK2 (0.46) | JAK2JAK1TYK2JAK3METAP2 | |
| SCHEMBL9688738 | 0.74 | HTR1A (0.43) | HTR6HTR7HTR5AHTR1AHTR1D | |
| SCHEMBL9687754 | 0.74 | HTR6 (0.38) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL9688419 | 0.72 | SMN1; SMN2 (0.43) | HTR6 | |
| SCHEMBL31253211 | 0.63 | HTR2A (0.58) | HTR6HTR7HTR5AHTR1AHTR1D | |
| SCHEMBL21894631 | 0.62 | JAK2 (1.00) | JAK2JAK1TYK2JAK3NR3C1 | |
| SCHEMBL22864257 | 0.61 | NOS1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189473-B1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4958026-A | HYPOTENSIVE AGENTS | SCHERING AKTIENGESLLSCHAFT (DE) | 1990-09-18 | — | — | US | disclosed |