Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | METAP2 | P50579 | 4/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689897 | 0.84 | MTNR1A (0.41) | METAP2 | |
| SCHEMBL9688718 | 0.81 | HTR6 (0.34) | HTR6HTR5A | |
| SCHEMBL9687964 | 0.80 | JAK2 (0.45) | METAP2HTR6HTR1DHTR5A | |
| SCHEMBL9688738 | 0.77 | HTR1A (0.43) | HTR6HTR1DHTR5A | |
| SCHEMBL9687754 | 0.74 | HTR6 (0.38) | ROCK2HTR6HTR1D | |
| SCHEMBL9688419 | 0.72 | SMN1; SMN2 (0.43) | HTR6 | |
| SCHEMBL9688716 | 0.64 | JAK2 (0.47) | METAP2 | |
| SCHEMBL31253212 | 0.63 | HTR1F (0.70) | HTR6HTR1DHTR5A | |
| SCHEMBL21894632 | 0.62 | GAA (0.64) | GAA | |
| SCHEMBL9671936 | 0.61 | KCNH2 (0.41) | ROCK2HTR1DHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189473-B1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4958026-A | HYPOTENSIVE AGENTS | SCHERING AKTIENGESLLSCHAFT (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0189473-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS. | SCHERING AG (DE) | 1986-08-06 | — | — | EP | disclosed |
| WO-1986001204-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-02-27 | — | — | WO | disclosed |