Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687970 | 0.90 | HTR1A (0.38) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL9689972 | 0.82 | HTR6 (0.41) | HTR1AHTR2A | |
| SCHEMBL2270614 | 0.82 | GPR84 (0.43) | — | |
| SCHEMBL9688933 | 0.80 | ADRB2 (0.47) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL9688833 | 0.79 | HTR1A (0.41) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL9689985 | 0.78 | HTR6 (0.39) | HTR1AHTR2A | |
| SCHEMBL9688999 | 0.75 | HTR1A (0.41) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL9689808 | 0.70 | HTR1A (0.43) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL9689122 | 0.70 | HTR1A (0.46) | HTR1AHTR2AHTR2CHTR2B | |
| SCHEMBL10869112 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189473-B1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4958026-A | HYPOTENSIVE AGENTS | SCHERING AKTIENGESLLSCHAFT (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0189473-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS. | SCHERING AG (DE) | 1986-08-06 | — | — | EP | disclosed |
| WO-1986001204-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-02-27 | — | — | WO | disclosed |