Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ARG1 | P05089 | 1/20 | 0.35 |
| ▸ | ARG2 | P78540 | 1/20 | 0.35 |
| ▸ | CYP2J2 | P51589 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24429270 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2TP53CNR1LMNAPKM | |
| SCHEMBL8972354 | 0.75 | TP53 (0.45) | SMN1; SMN2TP53CNR1LMNAPKM | |
| Hydrochloric Acid SCHEMBL8972193 | 0.74 | TP53 (0.44) | SMN1; SMN2TP53CNR1LMNAPKM | |
| SCHEMBL24703447 | 0.68 | ALDH1A1 (0.43) | SMN1; SMN2TP53LMNAPKMALDH1A1 | |
| SCHEMBL22735753 | 0.68 | LMNA (0.50) | SMN1; SMN2CNR1LMNAPKMALDH1A1 | |
| SCHEMBL24703507 | 0.68 | POLB (0.43) | SMN1; SMN2TP53LMNAPKMALDH1A1 | |
| SCHEMBL8744396 | 0.67 | TP53 (0.44) | SMN1; SMN2TP53ALDH1A1FPR3FPR2 | |
| SCHEMBL8765184 | 0.67 | MAPT (0.59) | SMN1; SMN2TP53LMNAPKMALDH1A1 | |
| Hydrochloric Acid SCHEMBL9868216 | 0.66 | MAPT (0.57) | SMN1; SMN2TP53LMNAALDH1A1FPR3 | |
| SCHEMBL18673236 | 0.66 | CYP2J2 (0.43) | SMN1; SMN2CYP2J2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468457-A1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | claimed |