Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31083416 | 0.88 | MAPT (0.56) | MAPTLMNASMN1; SMN2RAB9ATHRB | |
| SCHEMBL9036818 | 0.83 | MAPT (0.70) | MAPTLMNASMN1; SMN2THRBTP53 | |
| SCHEMBL11204672 | 0.82 | MAPT (0.54) | MAPTLMNASMN1; SMN2RAB9ATHRB | |
| SCHEMBL31426157 | 0.81 | MAPT (0.68) | MAPTLMNASMN1; SMN2RAB9ATHRB | |
| SCHEMBL9512394 | 0.81 | MAPT (0.68) | MAPTLMNASMN1; SMN2THRBTP53 | |
| SCHEMBL23117402 | 0.81 | MAPT (0.68) | MAPTLMNASMN1; SMN2THRBTP53 | |
| SCHEMBL23640304 | 0.80 | MAPT (0.49) | MAPTLMNASMN1; SMN2RAB9ATHRB | |
| SCHEMBL23115220 | 0.78 | MAPT (0.68) | MAPTLMNASMN1; SMN2TP53KDM4E | |
| SCHEMBL24796482 | 0.77 | LMNA (0.45) | MAPTLMNASMN1; SMN2RAB9ATHRB | |
| SCHEMBL10195130 | 0.77 | FAAH (0.42) | MAPTLMNASMN1; SMN2RAB9ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202991-A1 | BENZISOXAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2023-06-29 | — | — | US | disclosed |
| US-20230202991-A1 | BENZISOXAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2023-06-29 | — | — | US | disclosed |
| EP-4180090-A1 | BENZISOXAZOLE DERIVATIVE | Sumitomo Pharma Co., Ltd. (JP) | 2023-05-17 | — | — | EP | disclosed |
| US-11535599-B2 | Benzisoxazole derivative | Sumitomo Pharma Co., Ltd. (JP) | 2022-12-27 | — | — | US | disclosed |
| EP-0298921-B1 | 1,2-BENZISOXAZOLES AND 1,2-BENZISOTHIAZOLES | CIBA-GEIGY AG (CH) | 1992-12-23 | — | — | EP | disclosed |
| US-4957931-A | ANTICONVULSANTS, TREATMENT OF EPILEPSY | CIBA-GEIGY CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
| US-4859691-A | Certain 1,2-benzisoxazole derivatives | CIBA-GEIGY CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |
| EP-0298921-A1 | 1,2-Benzisoxazoles and 1,2-benzisothiazoles | CIBA-GEIGY AG (CH) | 1989-01-11 | — | — | EP | disclosed |
| EP-0073645-B1 | 2-CYCLIC AMINO-2-(1,2-BENZISOXAZOL-3-YL)ACETIC ACID ESTER DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND COMPOSITION CONTAINING THE SAME | Dainippon Pharmaceutical Co., Ltd. (JP) | 1986-11-12 | — | — | EP | disclosed |
| US-4447439-A | ANTICHOLINERGIC, ANTISPASMODIC AGENT | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1984-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11535599-B2 | Benzisoxazole derivative | HDAC3, GABRA5, HDAC2 | MAPT 933/4885LMNA 4416/4885SMN1; SMN2 1379/4885 |
| US-20230202991-A1 | BENZISOXAZOLE DERIVATIVE | HDAC3, GABRA5, HDAC2 | MAPT 933/4885LMNA 4416/4885SMN1; SMN2 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.