Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688864 | 0.85 | TSHR (0.44) | GSK3BTSHRHPGDSMEN1KMT2A | |
| SCHEMBL9689246 | 0.85 | TSHR (0.44) | GSK3BTSHRHPGDSMEN1KMT2A | |
| SCHEMBL9689262 | 0.77 | CNR2 (0.36) | GSK3BTSHRMEN1KMT2ALMNA | |
| SCHEMBL9688754 | 0.77 | RECQL (0.43) | TSHRMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9689070 | 0.76 | SMN1; SMN2 (0.48) | MEN1KMT2ALMNAALDH1A1NPC1 | |
| SCHEMBL9688818 | 0.76 | RECQL (0.66) | TSHRMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL9689245 | 0.76 | HPGD (0.46) | TSHRKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL5216245 | 0.76 | NPC1 (0.50) | TSHRHPGDSMEN1KMT2ALMNA | |
| SCHEMBL9689342 | 0.75 | ALDH1A1 (0.43) | TSHRLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL9688824 | 0.73 | TSHR (0.38) | TSHRHPGDSMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |