Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689245 | 0.89 | HPGD (0.46) | ALDH1A1TSHRSMN1; SMN2HPGDRAB9A | |
| SCHEMBL9689977 | 0.84 | TDP1 (0.36) | ALDH1A1TSHRSMN1; SMN2RORCTDP1 | |
| SCHEMBL9689107 | 0.83 | TDP1 (0.41) | ALDH1A1TSHRSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9688628 | 0.81 | ALDH1A1 (0.52) | ALDH1A1TSHRSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9687989 | 0.81 | ELANE (0.38) | ALDH1A1TSHRHPGDKDM4ETDP1 | |
| SCHEMBL9689319 | 0.78 | TSHR (0.43) | ALDH1A1TSHRSMN1; SMN2HPGDRAB9A | |
| SCHEMBL9688014 | 0.78 | NPC1 (0.47) | ALDH1A1TSHRSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9689730 | 0.78 | ALDH1A1 (0.45) | ALDH1A1TSHRSMN1; SMN2HPGDRAB9A | |
| SCHEMBL9687992 | 0.76 | ALDH1A1 (0.39) | ALDH1A1TSHRTDP1MAPTMAPK1 | |
| SCHEMBL9689183 | 0.75 | GSK3B (0.47) | ALDH1A1TSHRSMN1; SMN2HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |