Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 7/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689342 | 0.89 | ALDH1A1 (0.43) | HPGDTSHRALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9689149 | 0.82 | LMNA (0.39) | TSHRCYP3A4ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9689112 | 0.82 | NPC1 (0.40) | HPGDALDH1A1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL9690007 | 0.81 | RECQL (0.54) | TSHRCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL9689339 | 0.81 | MEN1 (0.36) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9792318 | 0.80 | HPGD (0.45) | HPGDTSHRALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9687969 | 0.78 | NPC1 (0.52) | ALDH1A1SMN1; SMN2KMT2ARAB9AMAPT | |
| SCHEMBL9688171 | 0.77 | PADI1 (0.41) | HPGDTSHRCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11088045 | 0.77 | HPGD (0.43) | HPGDTSHRALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9690049 | 0.76 | ALDH1A1 (0.39) | TSHRALDH1A1L3MBTL1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |