Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689149 | 0.91 | LMNA (0.39) | TDP1ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL9689342 | 0.84 | ALDH1A1 (0.43) | TDP1ALDH1A1L3MBTL1TSHRMAPK1 | |
| SCHEMBL9689107 | 0.81 | TDP1 (0.41) | TDP1ALDH1A1L3MBTL1TSHRMAPK1 | |
| SCHEMBL9688628 | 0.80 | ALDH1A1 (0.52) | TDP1ALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL9687989 | 0.80 | ELANE (0.38) | TDP1ALDH1A1L3MBTL1TSHRMAPK1 | |
| SCHEMBL9689262 | 0.79 | CNR2 (0.36) | ALDH1A1TSHRMAPK1LMNAMAPT | |
| SCHEMBL9689866 | 0.79 | MAPT (0.35) | ALDH1A1TSHRMAPK1LMNAMAPT | |
| SCHEMBL9689705 | 0.79 | MAPT (0.35) | ALDH1A1TSHRMAPK1LMNAMAPT | |
| SCHEMBL9688014 | 0.78 | NPC1 (0.47) | TDP1ALDH1A1L3MBTL1TSHRMAPK1 | |
| SCHEMBL9689319 | 0.76 | TSHR (0.43) | TDP1ALDH1A1L3MBTL1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486807-A1 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| US-5082951-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (I) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |