Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | CDC42 | P60953 | 1/20 | 0.36 |
| ▸ | RAC1 | P63000 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689396 | 0.84 | KDM4E (0.49) | TDP1KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9690579 | 0.83 | KDM4E (0.45) | KDM4EALDH1A1PTGS2CYP1A2SMN1; SMN2 | |
| SCHEMBL9690031 | 0.77 | TDP1 (0.40) | TDP1KDM4EALDH1A1GAAAKR1C3 | |
| SCHEMBL9689940 | 0.75 | TDP1 (0.40) | TDP1KDM4EALDH1A1GAAAKR1C3 | |
| SCHEMBL9690025 | 0.74 | PPARA (0.42) | TDP1KDM4EALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL9690573 | 0.69 | KDM4E (0.43) | KDM4EALDH1A1CYP1A2TSHRPOLB | |
| SCHEMBL9469004 | 0.65 | TDP1 (0.42) | TDP1KDM4EALDH1A1GAAAKR1C3 | |
| SCHEMBL9689963 | 0.65 | HDAC3 (0.43) | KDM4EALDH1A1HPGD | |
| SCHEMBL9689975 | 0.63 | GPR139 (0.37) | TDP1KDM4EALDH1A1GAATSHR | |
| SCHEMBL9469693 | 0.62 | KDM4E (0.46) | KDM4EALDH1A1GAAAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506011-A1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-09-30 | — | — | EP | disclosed |