Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | CDC42 | P60953 | 1/20 | 0.38 |
| ▸ | RAC1 | P63000 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690031 | 0.92 | TDP1 (0.40) | TDP1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL9690657 | 0.87 | NPSR1 (0.38) | POLBPPARA | |
| SCHEMBL9689971 | 0.87 | ALDH1A1 (0.35) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL9689482 | 0.85 | ALDH1A1 (0.34) | KDM4EALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL9688895 | 0.82 | KDM4E (0.43) | PTGS2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9689975 | 0.77 | GPR139 (0.37) | TDP1TSHRKDM4EALDH1A1HPGD | |
| SCHEMBL9689951 | 0.77 | TDP1 (0.41) | TDP1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL9688515 | 0.76 | ALDH1A1 (0.38) | TDP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9689398 | 0.75 | TDP1 (0.41) | TDP1AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL9690025 | 0.75 | PPARA (0.42) | TDP1AKR1C3AKR1C2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506011-A1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-09-30 | — | — | EP | disclosed |