Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 13/20 | 0.59 |
| ▸ | CASP5 | P51878 | 13/20 | 0.59 |
| ▸ | CASP4 | P49662 | 11/20 | 0.57 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689427 | 0.84 | CASP1 (0.65) | CASP1CASP5CASP4TSHRKDM4E | |
| SCHEMBL11900784 | 0.75 | MPO (0.54) | CASP1CASP5CASP4TSHRMAPT | |
| SCHEMBL6139027 | 0.73 | CASP1 (0.56) | CASP1CASP5CASP4TSHRKDM4E | |
| SCHEMBL9690117 | 0.72 | CASP1 (0.54) | CASP1CASP5CASP4GAAMAPT | |
| SCHEMBL10367766 | 0.72 | CASP1 (0.56) | CASP1CASP5CASP4TSHRKDM4E | |
| SCHEMBL9755201 | 0.72 | MEN1 (0.73) | CASP1CASP5CASP4TSHRKDM4E | |
| SCHEMBL29754406 | 0.72 | CASP1 (0.80) | CASP1CASP5CASP4KMT2ASMN1; SMN2 | |
| SCHEMBL9703381 | 0.71 | LMNA (0.40) | ACHETSHRGFERKDM4EGAA | |
| SCHEMBL9688232 | 0.71 | CASP1 (0.52) | CASP1CASP5CASP4GAAMAPT | |
| Hydrochloric Acid SCHEMBL9639434 | 0.71 | KMT2A (0.71) | CASP1CASP5CASP4KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | claimed |
| EP-0293078-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1988-11-30 | — | — | EP | claimed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | claimed |
| US-5120843-A | Nervous system disorders | UPJOHN (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0487510-A1 | Pharmaceutically active amines | THE UPJOHN COMPANY (US) | 1992-05-27 | — | — | EP | disclosed |
| EP-0358676-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |
| WO-1988008424-A1 | PHARMACEUTICALLY ACTIVE AMINES | THE UPJOHN COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |