Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10786897 | 0.90 | ADORA3 (0.52) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9691613 | 0.86 | ADORA3 (0.49) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9689715 | 0.86 | ADORA3 (0.49) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL11203237 | 0.83 | CACNA1C (0.48) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10786550 | 0.82 | CACNA1F (0.53) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10782467 | 0.81 | ALDH1A1 (0.50) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10781987 | 0.80 | ALDH1A1 (0.50) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL11008624 | 0.79 | ADORA3 (0.68) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9691059 | 0.78 | CACNA1F (0.50) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL10770890 | 0.78 | ADORA3 (0.44) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |
| EP-0071819-B1 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1987-04-22 | — | — | EP | disclosed |
| EP-0071819-A1 | Dihydropyridines with a positive inotropic activity, their use in pharmaceutical preparations, and processes for their preparation | BAYER AG (DE) | 1983-02-16 | — | — | EP | disclosed |