Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | NOS1 | P29475 | 3/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689684 | 0.89 | NOS1 (0.43) | HTR6NOS1AOC3HTR1ANOS3 | |
| SCHEMBL9687943 | 0.85 | HTR6 (0.46) | HTR6NOS1AOC3HTR1ANOS3 | |
| SCHEMBL9688833 | 0.81 | HTR1A (0.41) | HTR6HTR1APNPHTR2A | |
| SCHEMBL9688854 | 0.81 | PDE4B (0.47) | HTR6NOS1AOC3HTR1ANOS3 | |
| SCHEMBL9689972 | 0.80 | HTR6 (0.41) | HTR6NOS1AOC3HTR1ANOS3 | |
| SCHEMBL5924181 | 0.77 | NQO2 (0.42) | PNP | |
| SCHEMBL9689134 | 0.75 | HTR6 (0.50) | HTR6NOS1AOC3HTR1ANOS3 | |
| SCHEMBL9689621 | 0.75 | HTR6 (0.47) | HTR6NOS1AOC3HTR1AHTR2A | |
| SCHEMBL9688843 | 0.75 | HTR1A (0.41) | HTR6HTR1APNPHTR2A | |
| SCHEMBL9687954 | 0.74 | HTR6 (0.43) | HTR6NOS1AOC3HTR1ANOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0189473-B1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4958026-A | HYPOTENSIVE AGENTS | SCHERING AKTIENGESLLSCHAFT (DE) | 1990-09-18 | — | — | US | disclosed |
| EP-0189473-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS. | SCHERING AG (DE) | 1986-08-06 | — | — | EP | disclosed |
| WO-1986001204-A1 | NEW DOPAMINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, AND THEIR USE AS MEDICINAL PRODUCTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-02-27 | — | — | WO | disclosed |