Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10814837 | 0.94 | POLB (0.41) | GAAKDM4ENR1I2SIRT1TACR1 | |
| SCHEMBL9691359 | 0.92 | POLB (0.44) | GAAKDM4ENR1I2SIRT1POLB | |
| SCHEMBL9691648 | 0.91 | TP53 (0.41) | GAAKDM4ENR1I2SIRT1POLB | |
| SCHEMBL10914095 | 0.88 | POLB (0.46) | GAAKDM4ENR1I2SIRT1POLB | |
| SCHEMBL9691625 | 0.88 | NR1I2 (0.42) | GAAKDM4ENR1I2SIRT1POLB | |
| SCHEMBL9691796 | 0.87 | HTR6 (0.43) | GAAKDM4ENR1I2SIRT1FFAR1 | |
| SCHEMBL9691807 | 0.87 | SLC1A5 (0.44) | KDM4ESMN1; SMN2FFAR1MAPTHTT | |
| SCHEMBL9690877 | 0.87 | HTR6 (0.43) | GAAKDM4ENR1I2TACR1FFAR1 | |
| SCHEMBL9690807 | 0.85 | POLB (0.44) | GAAKDM4ENR1I2SIRT1POLB | |
| SCHEMBL10647063 | 0.85 | POLB (0.43) | GAAKDM4ENR1I2SIRT1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |