Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10817795 | 0.95 | ABCB1 (0.46) | SLC1A5MTNR1AMTNR1BABCB1HTR1A | |
| SCHEMBL9691359 | 0.90 | POLB (0.44) | HTR1AKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL9691796 | 0.89 | HTR6 (0.43) | AKR1C3KDM4EFFAR1MRGPRX4 | |
| SCHEMBL10914095 | 0.87 | POLB (0.46) | HTR1AKDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL9690850 | 0.87 | GAA (0.40) | KDM4EFFAR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL9690786 | 0.86 | MEN1 (0.48) | ABCB1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9689534 | 0.86 | FFAR4 (0.44) | SLC1A5MRGPRX4 | |
| SCHEMBL9691648 | 0.85 | TP53 (0.41) | SLC1A5KDM4EMAPTHTTSMN1; SMN2 | |
| SCHEMBL9690877 | 0.85 | HTR6 (0.43) | HTR1AKDM4EFFAR1MAPT | |
| SCHEMBL9691625 | 0.85 | NR1I2 (0.42) | SLC1A5HTR1AKDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |