Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 4/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10815688 | 0.94 | HTR6 (0.47) | HTR6FFAR1TACR1PTPRCPTPN1 | |
| SCHEMBL10649783 | 0.91 | HTR6 (0.41) | HTR6FFAR1TACR1PTPRCPTPN1 | |
| SCHEMBL9691359 | 0.88 | POLB (0.44) | KDM4EGAAMAPTNR1I2HTR1A | |
| SCHEMBL10646848 | 0.88 | HTR6 (0.43) | HTR6FFAR1TACR1KDM4EGAA | |
| SCHEMBL9691648 | 0.88 | TP53 (0.41) | KDM4EGAANPC1MAPTRAB9A | |
| SCHEMBL9691625 | 0.87 | NR1I2 (0.42) | KDM4EGAAMAPTRAB9ANR1I2 | |
| SCHEMBL9690850 | 0.87 | GAA (0.40) | FFAR1TACR1KDM4EGAAMAPT | |
| SCHEMBL9689430 | 0.86 | ALDH1A1 (0.43) | KDM4EGAAMAPTNR1I2SLC6A3 | |
| SCHEMBL9690847 | 0.86 | FABP4 (0.45) | FFAR1KDM4EGAANR1I2 | |
| SCHEMBL9691807 | 0.85 | SLC1A5 (0.44) | FFAR1KDM4EMAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0071819-B2 | DIHYDROPYRIDINES WITH A POSITIVE INOTROPIC ACTIVITY, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESSES FOR THEIR PREPARATION | BAYER AG (DE) | 1992-06-10 | — | — | EP | disclosed |
| EP-0288758-A2 | Dihydropyridinamides, process for their preparation and their use in medicines | BAYER AG (DE) | 1988-11-02 | — | — | EP | disclosed |