Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825506 | 0.88 | SLC6A1 (0.47) | KCNH2LMNABLMKDM4EALDH1A1 | |
| SCHEMBL9824935 | 0.84 | KCNH2 (0.48) | KCNH2HTR2ADRD2DRD3PTGDR2 | |
| SCHEMBL10395490 | 0.83 | LMNA (0.46) | LMNACHRM2CHRM4CHRM5THRB | |
| Hydrochloric Acid SCHEMBL10394912 | 0.82 | LMNA (0.45) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL10685083 | 0.81 | KCNH2 (0.52) | KCNH2 | |
| SCHEMBL9692552 | 0.78 | HTT (0.47) | LMNACHRM2CHRM4CHRM5THRB | |
| Hydrochloric Acid SCHEMBL9692396 | 0.78 | HTT (0.46) | LMNACHRM2CHRM4CHRM5THRB | |
| SCHEMBL9692507 | 0.76 | MALT1 (0.43) | KCNH2LMNACHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL9692497 | 0.75 | MALT1 (0.42) | KCNH2LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL9824929 | 0.75 | KCNH2 (0.49) | KCNH2HTR2ADRD2DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252005-B1 | HYDROGENATED 1-BENZOOXACYCLOALKYL-PYRIDINE CARBOXYLIC-ACID COMPOUNDS | CIBA-GEIGY AG (CH) | 1991-07-10 | — | — | EP | claimed |
| US-5112855-A | Nootropic Agents | CIBA-GEIGY CORPORATION (US) | 1992-05-12 | — | — | US | disclosed |
| US-4957928-A | NOOTROPIC AGENTS, COGNITION ACTIVATORS | CIBA-GEIGY CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |