SCHEMBL9695572

SCHEMBL9695572

CC(O[Si](C)(C)C(C)(C)C)C(CNCc1ccccc1)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.44
SMN1; SMN2 Q16637 4/20 0.39
KMT2A Q03164 4/20 0.39
MEN1 O00255 3/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPT P10636 1/20 0.39
CYP2D6 P10635 2/20 0.38
ANPEP P15144 1/20 0.38
CYP1A2 P05177 1/20 0.38
BCHE P06276 3/20 0.37
KDM4E B2RXH2 1/20 0.36
MITF O75030 1/20 0.36
GAA P10253 1/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9462196 0.88 MEN1 (0.44) ATMKMT2AMEN1ALDH1A1ANPEP
SCHEMBL9461991 0.88 MEN1 (0.44) ATMKMT2AMEN1ALDH1A1ANPEP
SCHEMBL9314679 0.88 SMN1; SMN2 (0.47) ATMSMN1; SMN2KMT2AMEN1ALDH1A1
SCHEMBL2109163 0.80 MCHR1 (0.44) ATMSMN1; SMN2KMT2AMEN1ALDH1A1
SCHEMBL2112075 0.80 MCHR1 (0.44) ATMSMN1; SMN2KMT2AMEN1ALDH1A1
SCHEMBL8631335 0.77
SCHEMBL8431959 0.75 FAAH (0.30) KMT2AMEN1ALDH1A1ANPEP
SCHEMBL17754429 0.74 ATM (0.43) ATMKMT2AMEN1ALDH1A1CYP2D6
SCHEMBL16400871 0.74 SIGMAR1 (0.44) SMN1; SMN2KMT2AMEN1ALDH1A1CYP2D6
SCHEMBL17686415 0.73 TRPV3 (0.42) SMN1; SMN2KMT2AMEN1BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1992006978-A1 1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC ACID COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-04-30 WO disclosed