SCHEMBL9696240

SCHEMBL9696240

COC(=O)c1ccc(C(=O)Oc2ccc(C(O)CN(C)C(=O)OCc3ccccc3)cc2OC(=O)C(C)C)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 14/20 0.43
ALDH1A1 P00352 8/20 0.43
TSHR P16473 7/20 0.43
MAPT P10636 5/20 0.41
TP53 P04637 1/20 0.41
MAPK1 P28482 3/20 0.40
KDM4E B2RXH2 1/20 0.40
NPC1 O15118 1/20 0.40
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
HSD17B10 Q99714 1/20 0.40
ALOX15 P16050 1/20 0.39
ADRB2 P07550 1/20 0.39
ADRA2A P08913 1/20 0.39
DRD2 P14416 1/20 0.39
ADRA2C P18825 1/20 0.39
DRD1 P21728 1/20 0.39
ADRA1A P35348 1/20 0.39
DRD3 P35462 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9344930 0.93 MAPT (0.40) CYP3A4ALDH1A1TSHRMAPTHPGD
SCHEMBL9348914 0.93 MAPT (0.40) CYP3A4ALDH1A1TSHRMAPTHPGD
SCHEMBL9345469 0.93 ELANE (0.40) CYP3A4ALDH1A1TSHRMAPTHPGD
SCHEMBL9344950 0.86 MAPT (0.40) CYP3A4ALDH1A1TSHRMAPTHPGD
SCHEMBL2790849 0.84 CYP3A4 (0.51) CYP3A4ALDH1A1TSHRMAPTMAPK1
SCHEMBL9696523 0.84 MAPT (0.42) CYP3A4ALDH1A1TSHRMAPTTP53
SCHEMBL9696017 0.82 CA1 (0.39) ALDH1A1KDM4EALOX15ADRB2ADRA2A
SCHEMBL21462592 0.82 MEN1 (0.40) CYP3A4ALDH1A1MAPTKDM4EHPGD
SCHEMBL9696527 0.81 ALOX15 (0.43) CYP3A4ALDH1A1TSHRMAPTTP53
SCHEMBL23055623 0.77 APP (0.42) KDM4ENPC1GAAHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5144059-A CATECHOLAMINE ESTERS SIMES SOCIETA ITALIANA MEDICINALI E. SINTETICI S.A. (IT) 1992-09-01 US disclosed