Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of Sanguinarium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAD | Q92934 | 7/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | HPGD | P15428 | 6/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | LMNA | P02545 | 4/20 | 0.77 |
| ▸ | ACHE | P22303 | 4/20 | 0.77 |
| ▸ | TP53 | P04637 | 3/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.77 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | BCHE | P06276 | 3/20 | 0.77 |
| ▸ | RGS12 | O14924 | 2/20 | 0.77 |
| ▸ | RGS17 | Q9UGC6 | 2/20 | 0.77 |
| ▸ | NPC1 | O15118 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sanguinarium SCHEMBL9405581 | 0.91 | BAD (0.84) | BADALDH1A1MAPTHPGDSMN1; SMN2 | |
| Sanguinarium SCHEMBL30153784 | 0.88 | BAD (1.00) | BADALDH1A1MAPTHPGDSMN1; SMN2 | |
| Sanguinarium SCHEMBL30129850 | 0.88 | BAD (1.00) | BADALDH1A1MAPTHPGDSMN1; SMN2 | |
| Sanguinarium SCHEMBL29385229 | 0.88 | BAD (1.00) | BADALDH1A1MAPTHPGDSMN1; SMN2 | |
| Sanguinarium SCHEMBL123241 | 0.88 | BAD (1.00) | BADALDH1A1MAPTHPGDSMN1; SMN2 | |
| Sanguinarium SCHEMBL23524622 | 0.88 | BAD (1.00) | BADALDH1A1MAPTHPGDSMN1; SMN2 | |
| Sanguinarium SCHEMBL454298 | 0.87 | ALDH1A1 (0.91) | BADALDH1A1MAPTHPGDSMN1; SMN2 | |
| Sanguinarium SCHEMBL43290 | 0.87 | RAC1 (1.00) | BADALDH1A1MAPTHPGDSMN1; SMN2 | |
| Sanguinarium SCHEMBL30668087 | 0.87 | RAC1 (1.00) | BADALDH1A1MAPTHPGDSMN1; SMN2 | |
| Sanguinarium SCHEMBL8584009 | 0.87 | BAD (0.97) | BADALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992000104-A1 | MUCOSAL DELIVERY SYSTEMS FOR TREATMENT OF PERIODONTAL DISEASE | ATRIX LABORATORIES, INC. (US) | 1992-01-09 | — | — | WO | claimed |
| US-4975271-A | Muscosal delivery systems for treatment of periodontal disease | VIPONT PHARMACEUTICAL, INC. (US) | 1990-12-04 | — | — | US | claimed |
| WO-1992000104-A1 | MUCOSAL DELIVERY SYSTEMS FOR TREATMENT OF PERIODONTAL DISEASE | ATRIX LABORATORIES, INC. (US) | 1992-01-09 | — | — | WO | disclosed |
| US-4975271-A | Muscosal delivery systems for treatment of periodontal disease | VIPONT PHARMACEUTICAL, INC. (US) | 1990-12-04 | — | — | US | disclosed |