Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 10/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | VDR | P11473 | 6/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700544 | 1.00 | ACSS2 (0.36) | ACSS2CYP1A2KDM4EAGTR1LMNA | |
| SCHEMBL10570571 | 1.00 | ACSS2 (0.36) | ACSS2CYP1A2KDM4EAGTR1LMNA | |
| SCHEMBL9700622 | 0.71 | CYP1A2 (0.36) | ACSS2CYP1A2KDM4EAGTR1LMNA | |
| SCHEMBL9699455 | 0.67 | KCNJ5 (0.35) | KDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL9700504 | 0.67 | ALDH1A1 (0.38) | TSHR | |
| SCHEMBL9700533 | 0.67 | ALDH1A1 (0.38) | TSHR | |
| SCHEMBL11220147 | 0.65 | CYP1A2 (0.41) | CYP1A2KDM4EAGTR1LMNAMEN1 | |
| SCHEMBL6522822 | 0.64 | TK1 (0.46) | ACSS2CYP1A2KDM4EAGTR1LMNA | |
| SCHEMBL465454 | 0.64 | TK1 (0.46) | ACSS2CYP1A2KDM4EAGTR1LMNA | |
| SCHEMBL10843840 | 0.64 | HTR1A (0.41) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5082939-A | Pyridazine derivatives | I.S.F. SOCIETA PER AZIONI (IT) | 1992-01-21 | — | — | US | disclosed |
| US-4873328-A | Process for preparing alkoxyalkylidenehydrazinopyridazine derivatives | I.S.F. SOCIETA PER AZIONI (IT) | 1989-10-10 | — | — | US | disclosed |
| EP-0274409-A2 | Process for preparing alkoxyalkyl-idenehydrazinopyridazine derivatives | I.S.F. Socièta per Azioni (IT) | 1988-07-13 | — | — | EP | disclosed |