Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 3/20 | 0.35 |
| ▸ | GABRD | O14764 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327396 | 0.81 | KDM4E (0.40) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL8547768 | 0.81 | KDM4E (0.40) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL8545718 | 0.77 | KDM4E (0.37) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL9684853 | 0.75 | ALDH1A1 (0.45) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL1171022 | 0.72 | KDM4E (0.45) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL19857472 | 0.72 | KDM4E (0.45) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL353523 | 0.71 | KDM4E (0.44) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL19857468 | 0.71 | GABRP (0.44) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL1819716 | 0.71 | GABRP (0.44) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL617721 | 0.71 | KDM4E (0.44) | KDM4EALDH1A1CYP3A4MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166060-A | Prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acid | CELGENE CORPORATION (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0390102-A2 | Process for the preparation of pyridine-2,3-dicarboxylic acids | CELGENE CORPORATION (US) | 1990-10-03 | — | — | EP | disclosed |