Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 15/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE6D | O43924 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
| ▸ | PDE6G | P18545 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701433 | 1.00 | PDE5A (0.33) | PDE5APDE3BPDE3AKDM4EXBP1 | |
| SCHEMBL9526087 | 0.88 | ALOX5 (0.36) | KDM4EMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9526095 | 0.88 | ALOX5 (0.36) | KDM4EMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9524898 | 0.85 | PDE4A (0.37) | PDE5AKDM4EXBP1MEN1ALDH1A1 | |
| SCHEMBL9701474 | 0.80 | CYP1A2 (0.41) | KDM4EALDH1A1CYP1A2MAPTHPGD | |
| SCHEMBL9702672 | 0.80 | KDM4E (0.30) | KDM4EALDH1A1 | |
| SCHEMBL9702682 | 0.80 | KDM4E (0.30) | KDM4EALDH1A1 | |
| SCHEMBL9700689 | 0.79 | RAB9A (0.33) | PDE5AKDM4EGCGRMEN1ALDH1A1 | |
| SCHEMBL9526113 | 0.79 | MAPT (0.41) | KDM4EMEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL9700644 | 0.79 | PDE5A (0.38) | PDE5AKDM4EGCGRMEN1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | claimed |
| WO-1992006085-A1 | PHENYLPYRIDINOL DERIVATIVES AS MEDICAMENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |