Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700908 | 0.78 | HTR1B (0.57) | LMNAHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL9701919 | 0.77 | MEN1 (0.43) | HPGDMAPTKDM4ERECQLTDP1 | |
| SCHEMBL9701657 | 0.77 | AOC2 (0.55) | LMNAALDH1A1ALOX15MAPTKDM4E | |
| SCHEMBL9703273 | 0.76 | LMNA (0.37) | LMNAALDH1A1CYP3A4MAPK1GAA | |
| SCHEMBL9701892 | 0.73 | TAAR1 (0.44) | LMNAHPGDHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL25409990 | 0.73 | KDM4E (0.59) | LMNAHPGDHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL9702218 | 0.73 | APP (0.43) | MAPK1TAAR1 | |
| SCHEMBL9702021 | 0.73 | MAOB (0.50) | ALOX15AOC2MAOAMAOBTAAR1 | |
| SCHEMBL9701922 | 0.71 | ESR1 (0.41) | LMNACYP3A4 | |
| SCHEMBL9701911 | 0.70 | TAAR1 (0.35) | LMNAHPGDHSD17B10ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5120764-A | Administering penicillamine and allenylamines to inhibit crosslinking of collagen | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0374440-A2 | Inhibitors of lysyl oxidase | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-27 | — | — | EP | disclosed |