Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3882288 | 0.82 | PSIP1 (0.50) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 | |
| SCHEMBL4250262 | 0.82 | PLCG1 (0.56) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 | |
| SCHEMBL7194392 | 0.82 | KEAP1 (0.57) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 | |
| SCHEMBL27498526 | 0.78 | KEAP1 (0.46) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 | |
| SCHEMBL11692985 | 0.78 | KEAP1 (0.46) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 | |
| SCHEMBL8765877 | 0.78 | KEAP1 (0.46) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 | |
| SCHEMBL385916 | 0.78 | KEAP1 (0.46) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 | |
| SCHEMBL27519579 | 0.78 | KEAP1 (0.46) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 | |
| SCHEMBL6097634 | 0.77 | KEAP1 (0.53) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 | |
| SCHEMBL9652718 | 0.76 | ALDH1A1 (0.43) | KEAP1NFE2L2RAPGEF4ALDH1A1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470543-A1 | Heterocyclic imidazoles, remedies containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-02-12 | — | — | EP | disclosed |