Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.46 |
| ▸ | LOX | P28300 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9354128 | 0.93 | LOXL2 (0.48) | LOXL2LOXMAPK1HPGDOPRM1 | |
| SCHEMBL9706016 | 0.93 | ALDH1A1 (0.43) | LOXL2LOXHPGDSMN1; SMN2 | |
| SCHEMBL9706102 | 0.90 | LOXL2 (0.46) | LOXL2LOXMAPK1HPGDOPRM1 | |
| SCHEMBL8781962 | 0.89 | LOXL2 (0.47) | LOXL2LOXMAPK1HPGDOPRM1 | |
| SCHEMBL9572972 | 0.87 | LOXL2 (0.46) | LOXL2LOXMAPK1HPGDCYP1A2 | |
| SCHEMBL9706010 | 0.82 | HPGD (0.44) | HPGD | |
| SCHEMBL9568958 | 0.82 | AAK1 (0.38) | HPGD | |
| SCHEMBL8782005 | 0.81 | ALDH1A1 (0.43) | LOXL2LOXHPGD | |
| SCHEMBL9572913 | 0.81 | ALDH1A1 (0.43) | LOXL2LOXHPGDSMN1; SMN2 | |
| SCHEMBL9566810 | 0.81 | LOXL2 (0.41) | LOXL2LOXHPGDOPRM1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479177-A2 | 4- or 5-substituted pyridine-2-carboxylic acids, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-04-08 | — | — | EP | disclosed |