Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | PTAFR | P25105 | 2/20 | 0.54 |
| ▸ | HRH1 | P35367 | 2/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | KDM6B | O15054 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5307781 | 0.88 | LTA4H (0.69) | LTA4HL3MBTL1CHRNA7GBA1ALDH1A1 | |
| SCHEMBL10734968 | 0.86 | ALDH1A1 (0.66) | LTA4HTDP1L3MBTL1PTAFRHRH1 | |
| SCHEMBL6159259 | 0.83 | SIGMAR1 (0.67) | TDP1L3MBTL1PTAFRHRH1TBXAS1 | |
| SCHEMBL9706520 | 0.83 | ALDH1A1 (0.53) | LTA4HL3MBTL1KDM6BKDM4CALDH1A1 | |
| SCHEMBL3465634 | 0.82 | L3MBTL1 (0.69) | L3MBTL1ALDH1A1MAPT | |
| SCHEMBL8199794 | 0.82 | TDP1 (0.71) | TDP1L3MBTL1PTAFRHRH1TBXAS1 | |
| SCHEMBL6161198 | 0.82 | SIGMAR1 (0.68) | TDP1L3MBTL1PTAFRHRH1 | |
| SCHEMBL6160313 | 0.82 | SIGMAR1 (0.68) | TDP1L3MBTL1PTAFRHRH1 | |
| SCHEMBL6191025 | 0.81 | KCNH3 (0.58) | L3MBTL1HRH1KDM6BKDM4CALDH1A1 | |
| SCHEMBL12040598 | 0.81 | HRH1 (0.72) | TDP1L3MBTL1HRH1TBXAS1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0198325-B1 | SUBSTITUTED ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-07-15 | — | — | EP | disclosed |
| US-4891429-A | CHEMICAL INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1990-01-02 | — | — | US | disclosed |
| US-4696930-A | CARDIOVASCULAR DISORDERS, ANTICOAGULANTS | HOFFMANN-LA ROCHE INC. (US) | 1987-09-29 | — | — | US | disclosed |
| EP-0198325-A2 | Substituted aniline derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-10-22 | — | — | EP | disclosed |